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KMID : 0923620220220010013
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Immune Network
2022 Volume.22 No. 1 p.13 ~ p.13
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The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease
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Park Chan-Su
Shastri Nilabh
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Abstract
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Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.
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KEYWORD
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T cells, Obese mice, Obesity-associated inflammation, Metabolic diseases, Insulin resistance
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